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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 Jan - 20 Jan 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
adopted in 2008
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Storage conditions: Ambient temperature (10 to 30 °C), dry
Water solubility:
ca. 176 g/L
Conc. based on:
test mat. (dissolved fraction)
Temp.:
20 °C
Remarks on result:
other: pH 2.5 at 24 °C

Results
Table 1 – Preliminary test results

Test item amount [mg]

Added vol. of distilled water [mL]

Total volume [mL]

Appearance of mixture

95.3

0.1

0.1

Not dissolved

0.4

0.5

0.5

1.0

Dissolved

 

Water solubility was found to be > 10 mg/L. Therefore, the flask method was used to determine water solubility of the test item.

After equilibration time, precipitate was seen in the flasks excluding the blank experiment. Water solubility was calculated from measured unrounded concentration values and not from rounded values.

Table 2 – Test item water solubility

Experiment

24 h experiment

48 h experiment

72 h experiment

Blank experiment (72 h)

Test item amount [g]

10.02

10.01

10.03

--

Demineralized water amount [mL]

10

 

Stirring time at 30 °C [h]

24

48

72

72

pH at 24 °C

2.5

6.4

Dilution factor

400

Measured concentration [mg/L]

438.87/433.20

448.33/439.89

444.62/438.87

--/--

Mean concentration [mg/L]

436.04

444.11

441.75

--

Water solubility [g/L]

174.4

177.6

176.7

--

 

The mean water solubility of the test item at 20 °C was determined to be cs= 176.3 g/L (± 1.66 g/L).

Description of key information

176 g/L (± 1.66 g/L) at 20 °C (OECD 105, Flask Method)

Key value for chemical safety assessment

Water solubility:
176 g/L
at the temperature of:
20 °C

Additional information