4,4'-trimethylenedipiperidine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1991

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Justification for type of information:

Guideline study under GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: U.S. 49 CFR 173.136 (a) and 173.137

Principles of method if other than guideline:

A U.S. DOT standard skin corrosion method was used.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-(1,3-Propanediyl)dipiperidine

Cas Number:

16898-52-5

Molecular formula:

C13H26N2

IUPAC Name:

1,1'-(1,3-Propanediyl)dipiperidine

Test material form:

solid

Details on test material:

Purity 100%, Brownish White Flaky Solid, Lot # 01008AA

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

6 white rabbits were used in the test study.

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

A 1 square inch quaze patch was held to the test area (intact skin)

Duration of treatment / exposure:

3 minutes, 60 minutes, and 4 hours

Observation period:

48 hours

Number of animals:

6

Details on study design:

Six animals were treated by introducing the test substance under gauze patches measuring 1 square inch held on with non-irritating tape at 3 test sites. The test substance was kept in contact with the skin for 3 minutes, 60 minutes, and 4 hours by wrapping with an impervious bandage. After the exposure period, the test sites were washed with sterile water. Initial readings were scored for erythema, edema and /or corrosion 30-60 minutes post exposure. Readings were made again at the end of 48 hours.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

48 h

Remarks on result:

no indication of irritation

Any other information on results incl. tables

None of the animals exhibited any signs of skin corrosion at any of the test sites. The test substance is not considered corrosive to the skin of albino rabbits according to the test study.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance is not considered corrosive to the skin of albino rabbits according to the guideline U.S. DOT corrosion test.