Registration Dossier
Registration Dossier
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EC number: 435-360-1 | CAS number: 144447-11-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance is positive in in vitro mammalian mutagenicity assays, it does not show a chemical structure activity relationship to known germ cel mutagens. Based on this the substance is not classified as a “germ cell mutagen”.
Furthermore the substance is used exclusively as a monomer in the production of a polymer, and not at all as an end-product. There is no monomer substance remaining after polymer production, and it is not possible to regenerate the monomer substance upon degradation of the polymer. Therefore no further in vivo studies are proposed.
Short description of key information:
The test substance in positive in the available in vitro genetic toxicity studies. The ames test, MLA and CA, respectively.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
The substance is positive in in vitro mammalian mutagenicity assays, it does not show a chemical structure activity relationship to known germ cel mutagens. Based on this the substance is not classified as a “germ cell mutagen”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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