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EC number: 911-381-6
CAS number: -
48-hour EC50: >2.9 µg/L (measured concentration) for the
effects of D5 on mobility of Daphnia magna,
read-across to Constituent 1, Vi5-D5. No effects were observed up to the
water solubility limit of the test substance.
48-h LL50: 272 mg/l loading rate (WAFs) for the effects of
Vi4-D4 on mobility of the marine copepod Acartia
tonsa. No effects were observed up to the water solubility limit of
the test substance.
There are no reliable short-term invertebrate toxicity data available
for the registration substance as a whole, therefore good quality data
from Constituent 2 and read-across from a structural analogue of
Constituent 1 have been read across.
The following data have been read across from
decamethylcyclopentasiloxane (D5, 541-02-6) for Constituent 1, Vi5-D5:
A 48-hour EC50 value of >2.9 µg/L (measured
concentration) has been determined for the effects of D5 on mobility of Daphnia
magna, in accordance with OECD guideline 202. A NOEC of ≥2.9 µg/L
has been determined in the same test (Springborn Smithers 2002). In view
of the test media preparation method of preparing a saturated stock
solution in acetone, and the flow-through exposure regime, it is likely
that the test organisms were exposed predominantly to the highest
achievable concentrations of the parent substance, and therefore there
were no effects observed up to the water solubility limit of the test
The following data are available for
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (Vi4-D4, CAS
A 48-h LL50 value of 272 mg/l and NOELR of
100 mg/l loading rate (WAFs) (not possible to extrapolate to measured
concentrations) have been determined for the effects of Vi4-D4 on
mobility of the marine copepod Acartia tonsa,
in accordance with ISO/FDIS 14669 a PARCOM ring test protocol (TNO,
2003). The LL50 is above the water
solubility limit of the substance (0.0073 – 0.0088 mg/l at 23°C). For
monoconstituent substances it would not normally be appropriate to test
at concentrations above the solubility limit. However, the results as
reported do provide strong evidence of the absence of toxicity at the
solubility limit of the substance following short-term exposures.
In view of the hydrolysis half-life of the test substance, the method of
preparation of the test solution (20 hours stirring at approximately pH
8) and the static exposure regime, it is likely that the test organisms
were exposed to a mixture of parent substance and hydrolysis product.
Refer to the discussion in the Section 6 endpoint summary for further
discussion of the approach to chemical safety assessment for this
registration substance, and justification for read-across used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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