Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well-documented, scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
according to Fed. Reg. 38, No. 187, § 1500.41 (Draize test)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 1-hydroxyethanesulphonate
EC Number:
213-037-4
EC Name:
Sodium 1-hydroxyethanesulphonate
Cas Number:
918-04-7
Molecular formula:
C2H6O4S.Na
IUPAC Name:
sodium 1-hydroxyethane-1-sulfonate
Details on test material:
Name of the test substance used in the study report: Acetaldehydbisulfit spezial = 1-Hydroxy-1-ethyl-natriumsulfonat

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
Acclimatization period: ca. 8 days before study start
Mean body weight: males 2.74 kg, females 2.82 kg
Singly housing in stainless steel wire mesh cages (area: 40 x 51 cm).
The animals were identified via ear tattoo.
Room temperature: 20 -26°C
Relative humidity: 50 - 80%
Day/night rhythm: 12 h light and 12 h darkness
The animals were offered a standard animal laboratory diet (about 130 g/animal/day) and tap water (about 250 ml/animal/day).

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded skin
Vehicle:
water
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
about 0.5 g of a 50% aqueous solution
Duration of treatment / exposure:
24 hours
Observation period:
8 days
Number of animals:
6
Details on study design:
Clipping of the fur: at least 15 hours before application
Application area: 2.5 x 2.5 cm (intact and abraded skin in each case)
Application site: upper third of the back
The test substance was not washed off.
Scoring according to J.H. Draize, 1959
Readings: 15 - 30 minutes after removal of the test patches as well as 48 h, 82 h and 8 day after application.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
0.7
Max. score:
1
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: application on intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
0
Remarks on result:
other: application on intact skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Score:
0.5
Max. score:
1
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: application on intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Score:
0
Max. score:
0
Remarks on result:
other: application on intact skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 8 days
Score:
0
Max. score:
0
Remarks on result:
other: application on intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 8 days
Score:
0
Max. score:
0
Remarks on result:
other: application on intact skin

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met