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EC number: 213-037-4 | CAS number: 918-04-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 1-hydroxyethanesulphonate
- EC Number:
- 213-037-4
- EC Name:
- Sodium 1-hydroxyethanesulphonate
- Cas Number:
- 918-04-7
- Molecular formula:
- C2H6O4S.Na
- IUPAC Name:
- sodium 1-hydroxyethane-1-sulfonate
- Details on test material:
- Name of the test substance used in the study report: Acetaldehydbisulfit spezial = 1-Hydroxy-1-ethyl-natriumsulfonat
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: at least one week
Animals with a comparable weight were used.
Age at study start: about 12 weeks
Five animals per cage (type: stainless steel wire mesh cages, DK-III).
The animals were identified via groups using cage cards.
Room temperature: 20 - 26!C
Relative humidity: 45 - 75%
Day/night rhythm: 12 h light and 12 h darkness
The animals were offered a standardized animal laboratory diet as well as tap water ad libitum. 16 hours before administration food deprivation (but water was available ad libitum).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The aqueous preparation (solution) corresponds to the physiological media.
Concentrations used were 21.5, 26.1, 31.6, 38.3 and 46.4% (G/V).
Administration volume: 10 ml/kg - Doses:
- 2150, 2610, 3160, 3830, 4640 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observation period: 14 days
Recording of signs and symptoms: > 15 min, 15 min, 30 min, 1 h, 2 h, 4 h and 5 h after administration, then once each working day. Check of moribund or dead animals twice each working days and once on public holidays.
Necropsy: 16 hours before killing with CO2 food deprivation; then necropsy with macroscopic-pathological examination. Necropsy of all animals that died as soon as possible.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 402 mg/kg bw
- Mortality:
- Male animals: 2150, 2610 and 3160 mg/kg: 0/5 after 14 days; 3830 mg/kg: 3/5 after 14 days; 4640 mg/kg: 5/5 after 14 days
Femalea nimals: 2150 mg/kg: 0/5 after 14 days; 2610 and 3160 mg/kg: 3/5 after 14 days; 3830 and 4640 mg/kg: 5/5 after 14 days - Clinical signs:
- other: Dyspnea, gasping, apathy, abnormal position, twitching, spastic gait, ruffled fur, ptosis, falling backwards, poor general state
- Gross pathology:
- Animals that died: Lung congestion, liver: passive hyperemia
Sacrificed animals: nothing abnormal detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
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