Registration Dossier
Registration Dossier
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EC number: 213-037-4 | CAS number: 918-04-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11.8 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 881.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- standard respiratory volume (rat) = 0.38 m³/kg/8h
- standard respiratory volume (human) = 6.7 m³/8h
- worker respiratory volume = 10 m³/8h
- absorption (oral, rat) = 50 % (default)
- absorption (inhalative, human) = 100 % (default)
--> modified dose descriptor (corrected inhalatory NOAEC) = oral NOAEL/0.38 x (50/100) x (6.7/10)
- AF for dose response relationship:
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for differences in duration of exposure:
- 6
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for other interspecies differences:
- 2.5
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for intraspecies differences:
- 5
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for the quality of the whole database:
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for remaining uncertainties:
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- route-to-route-extrapolation: factor 1
- AF for dose response relationship:
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for differences in duration of exposure:
- 6
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for other interspecies differences:
- 2.5
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for intraspecies differences:
- 5
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for the quality of the whole database:
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
- AF for remaining uncertainties:
- 1
- Justification:
- according to ECHA Guidance on information requirements and chemical safety assessment, Chapter R.8
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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