Registration Dossier
Registration Dossier
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EC number: 248-742-6 | CAS number: 27939-60-2
Endpoint summary
Administrative data
Description of key information
Bioaccumulation data in aquatic and terrestrial species is based on the available information (log Kow 3.1 and calculated BCF values). The BCFs for aquatic and terrestrial organisms were calculated using QSARs of Veith et al. (1979) and Jager (1998), both incorporated in the EUSES model, and yielded values of 86.1 and 15.9 L/kg ww, respectively.
Air-breathing organisms using data from DRAFT OECD TG 309: Vertoliff fulfils the screening criteria for concern for bioaccumulation in air breathing organisms: log Kow (3.1: >2) and log Koa (5.1: >5). Such bioaccumulation in air-breathing organisms may occur for non-metabolising substances because the lungs may present a less effective route for elimination compared to e.g. gills. Based on meeting the screening criteria for bioaccumulation in air-breathing organisms a water-simulation test (OECD TG 309) was performed to address the persistency of the substance and the bioaccumulation of the transformation products. In the OECD TG 309 study, Vertoliff degraded within minutes. Several transformation products were found and their log Kow were determined (HPLC using OECD TG 117). In total 8 regions of interest (ROI) were found. All ROIs were further characterised using log Kow. These log Kow decreased from ROI 8 (closest to Vertoliff) towards ROI 1, more polar products. The bioaccumulation assessment focussed on those ROIs which were exceeding the 10% at day 63 and were not transient. ROI 8, 7, 6, and 5 were all <10% after 63 days. ROIs 4 exceeded the 10% level at the high treatment group (100 µg/l) and ROI 3 at the low treatment group (10 µg/l). ROI 2 and 1 were increasing and >10% after day 63. ROI 4 to 1 all have log Kow values <2. This means that for all transformation products there is no concern for bioaccumulation in air-breathing organism either because of presence <10% or log Kow <2. In addition, there is information that Vertoliff metabolises in air-breathing organisms (see toxico-kinetic section) and the excretion pathway is via the kidneys further assuring absence of such bioaccumulation.
Additional information
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