2,4-dichlorobenzyl alcohol

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

No data provided.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Experimental studies with limited information provided.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1957

Report date:

1957

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Ear drops containing the test substance were tested for irritation properties on skin, eye and ear in rabbits.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dichlorobenzyl alcohol

EC Number:

217-210-5

EC Name:

2,4-dichlorobenzyl alcohol

Cas Number:

1777-82-8

Molecular formula:

C7H6Cl2O

IUPAC Name:

(2,4-dichlorophenyl)methanol

Results and discussion

Any other information on results incl. tables

Eye:

Lacrymation was observed within 30 min but was not detected after 2 h or later. The same effect was observed in the vehicle treated eye. During further observations the eyes appeared normal.

Skin:

No signs of irritation were observed after one application and after repeated application.

Ear:

There was no demonstrable damage to the outer ear of the guinea pigs after application. One ear treated with the control showed inflammatory responses. This effect was not detected in the other control ear and also not ears treated with polyethylene glycol alone in other experimental studies. The observed inflammation subsided by the sixth day following completion of treatment.