Registration Dossier
Registration Dossier
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EC number: 601-471-0 | CAS number: 117309-52-1
Endpoint summary
Administrative data
Description of key information
The acute toxicity to fish (Oncorhynchus mykiss) of NSABZ (2-(Naphthalene-2'-sulphonylamino)-benzoic acid) was evaluated.
A preliminary test on series of two fishes indicated that no mortality was expected for test item concentrations of 0.1 and 1.0 mg/L after a period of 4 days. Mortality was however observed for both fishes at a test item concentration of 10 mg/L.
A definitive study was carried out on series of 10 individuals with a concentration of 1.0 mg/L of test item for a period of 4 days. Two repetitions were performed. No mortality was observed.
Based on these results, it was therefore concluded that the LC50 value for 2-(Naphthalene-2'-sulphonylamino)-benzoic acid is > 1.0 mg/L. As this value is higher than the 1.0 mg/L threshold for classification as Acute Toxicity Category 1 of CLP, the substance 2-(Naphthalene-2'-sulphonylamino)-benzoic acid should therefore not be classified in the aquatic acute toxicity category of the CLP regulation.
However, since no data is available for chronic aquatic toxicity for the substance 2-(Naphthalene-2'-sulphonylamino)-benzoic acid, application of the CLP criteria leads to a classification of this substance as Toxic to aquatic life with long lasting effects (Aquatic Chronic 2).
Respiration inhibition of 2-(Naphthalene-2'-sulphonylamino)-benzoic acid on activated sludge was studied. The activated sludge was subjected to various concentrations of test substance for 3 consecutive hours.
A preliminary study was carried out with test substance concentrations of 10, 100 and 1000 mg/L.
Based on the results obtained in this preliminary test, it was decided to make new measurements on 10 mg/L replicates.
No significant respiration inhibition was found based on the 10 mg/L replicates.
The EC50 for respiration inhibition of activated sludge by 2-(Naphthalene-2'-sulphonylamino)-benzoic acid after 3 hours of exposure was therefore determined to be > 10 mg/L.
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