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Physical & Chemical properties

Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
December 2, 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
no
Type of method:
static method
Temp.:
298.15 K
Vapour pressure:
946.4 Pa
Vapour pressure:
3 505.8 Pa

Summary of Vapor Pressure Results

Summary of Vapor Pressure ResultsSample

Vapor Pressure

@ 283.15°K (Pa)

Vapor Pressure

@ 298.15°K (Pa)

Vapor Pressure

@ 323.15°K (Pa)

Vapor Pressure @ 348.15°K (Pa)

Sucrose Palmitate Stearate MDT Grade_1

< 80.0 *

946.4

3505.8

10437.4

* Lower detection limit of the transducer is 80.0 Pa

Conclusions:
The vapor pressure of the substance at 25 °C is 946.4 Pa.
Executive summary:

The vapor pressure of the test substance was determined in an OECD Guideline 104 study using the static method. The vapor pressure was determined at various temperatures. The vapor pressure at 25 °C was 946.4 Pa.

Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Qualifier:
according to guideline
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
- Software tool(s) used including version: EPI Suite v4.11
- Model(s) used: Mpbpwin Model version 1.43
The model is based on the Atom/Fragment Contribution (AFC) method from the work of Meylan and Howard (W.M. Meylan and P.H. Howard, Atom/fragment contribution method for estimating octanol-water partition coefficients, 1995, J. Pharm. Sci. 84: 83-92.), as implemented in the EPI Suite KOWWIN module (http://www.epa.gov/oppt/exposure/pubs/episuite.htm). The calculated model has a lower bound of -5.0 log units (all predictions lower than this value are set to -5.0). A dataset of compounds with experimental logP values has been built starting from the original dataset provided in EPI suite. The set has been processed and cleared from compounds that were replicated or that had problems with the provided molecule structure. The final dataset has 9,961 compounds.
- Model description: see field 'Justification for type of information', 'Attached justification' and 'any other information on Material and methods'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'overall remarks'
GLP compliance:
no
Type of method:
other: QSAR
Temp.:
25 °C
Vapour pressure:
0.588 Pa
Remarks on result:
other: For all components

Description of key information

0.588 Pa at 25 °C (Mp = 70 °C, Bp = 215.5°C) calculated with EpiSuite.

The experimental value 946.4 Pa at 25 °C measured according to OECD Guideline 104 (static method) is higher as expected for this substance due to the presence of a small content of water in the test substance and probable decomposition products of the substance formed during decomposition at 215.5 °C.

Key value for chemical safety assessment

Vapour pressure:
0.588 Pa
at the temperature of:
25 °C

Additional information