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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-02-22 to 2018-04-03
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 181
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: ECHA Guidance on Information Requirements and Chemical Saftey Assessment
Version / remarks:
Chapter R.7a: Endpoint specific guidance
Version 6.0, July 2017
Deviations:
no
GLP compliance:
no
Key result
Medium:
n-octanol
Solubility:
493 mg/L
Temp.:
20 °C

The determination of the saturation concentration of AFLAMMIT®PCO 962 in n-octanol at approximately 20°°C was performed during this study. The determination of the solubility was performed according to SOP 13.12.1 that is based on the method CIPAC MT 181.

An additional test using high performance liquid chromatography (HPLC) with refractive index (RI) detector was performed to determine the content of the active ingredient in the saturated solution in
n-octanol, i. e. the solubility of the test item in n-octanol.

 

The solubility of AFLAMMIT®PCO 962 in n-octanol was found to be < 10 g/l in the preliminary test.

 

In the additional test the solubility of AFLAMMIT®PCO 962 in n-octanol was determined to be
493 mg/l at approximately 20°C.

Conclusions:
The solubility of AFLAMMIT®PCO 962 in n-octanol was determined to be 493 mg/l at approximately 20°C.

Description of key information

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
493 mg/L

Additional information