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Registration Dossier
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EC number: 701-208-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The key skin sensitisation study for the category (Morris et al, 1997, HTR report number: 96-1104-70A,B; EC 701 -251 -5) was chosen as the study was conducted in humans which are the most relevant species. There is no recognised guideline for this type of test however a well documented study with good scientific principles was undertaken at a certified GLP laboratory which followed a protocol.
A standard Repeated Insult Patch Test was preceded by a Pilot Phase to select a proper concentration of the test material. The test material was tested undiluted and diluted to 50% in Mineral Oil. The negative control was Mineral Oil. The testing was conducted under semi-occluded patch conditions. A total of 24 subjects was tested; one half to undiluted test material and one half to 50% test material in mineral oil. Only minimal reactions were noted during the inductions and challenge so that undiluted test material was selected for testing in the Main Phase. A total of 104 additional subjects completed the Main Phase. The test material was tested undiluted. The negative control was Mineral Oil. The testing was conducted under occluded patch conditions. Only mild to moderate responses were noted during the main phase of the study, and it is concluded that the test material is non-irritating and non-sensitizing under the condition of this test.
A reliability rating of 1 according to the criteria of Klimisch, 1997.
The lack of skin sensitization in the human study is consistent with the negative results in multiple animal studies, including guinea pig Maximisation and Buehler studies on analog substances (EC 701 -251 -5; EC 701 -249 -4; EC 272 -388 -1).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No classification for skin sensitisation is warranted based on a negative HRIPT and multiple negative guinea pig studies for the alkyl phenate sulfide category.
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