Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Multiple studies with alkyl phenate sulfides (EC 701-251-5; EC 701-249-4; EC 272-388-1) demonstrate low acute toxicity and that no hazard classification is warranted.  

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Klimisch code 1 (reliable without restriction)

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
4 000 mg/kg bw
Quality of whole database:
Klimisch code 1 (reliable without restriction)

Additional information

Justification for classification or non-classification

Oral:

The key parameter chosen for acute toxicity for the oral route was greater than the classification criteria and, therefore, classification for acute toxicity was not considered to be necessary.

Dermal:

The key parameter chosen for acute toxicity for the dermal route was greater than the classification criteria and, therefore, classification for acute toxicity was not considered to be necessary.