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EC number: 701-208-0
CAS number: -
A weight of evidence is presented to demonstrate the lack of bioaccumulation potential for this substance. A BCF of 2.2 is assigned for risk assessment purposes and, while this value was obtained using an alternative method instead of, e.g., a standard OECD 305 fish bioconcentration study, this value is reasonable according to a weight of evidence approach.
study (Rausina et al., 1996) is considered to have a reliability of 2
according to the criteria of Klimisch, 1997 as the study was
well-conducted but a non-guideline and non-GLP study.
system utilizes Semipermeable Membrane Devices (SPMDs), first developed
by the United States Fish and Wildlife Service for field sampling
studies assessing environmental contamination. SPMDs are low-density
polyethylene tubing, with a pore-size similar to the cell membranes in
fish. SPMDs are filled with the lipid triolein, the predominant lipid in
fishes, and function as "model fish or mollusks" with selective
membranes and lipid reservoirs that concentrate organic compounds from
water. The BCF of EC 701-251-5 was determined to be 2.2 in this study.
modelled using LMC OASIS Catalogic BCF base-line (v.02.09) modeling
software, including multiple representative structures of this UVCB. The
predicted BCF was 7.76, which is consistent with the low BCF obtained
from the SPMD study.
code 1 OECD 305 and GLP study was conducted with TPP (EC 310-154-3),
which is present in the registered substance as a residual
impurity/constituent. The steady state BCF value assigned is 823.
Steady-state TPP concentrations were achieved in the tissues of rainbow
trout (Oncorhynchus mykiss) after 3 days for both the 1.1 and 11 μg/L
treatment groups. Steady-state BCF values based on total radioactivity
TPP concentrations were 289, 1601 and 823 in edible, nonedible and whole
fish tissue, respectively, for the 1.1 μg/L treatment group, and 289,
1428 and 749 in edible, nonedible and whole fish tissue, respectively,
for the 11 μg/L treatment group. TPP was eliminated quickly with mean
tissue concentrations 10% or less than the mean measured steady-state
test concentrations by Day 11.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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