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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Although no guideline was followed the study contains sufficient experimental details to be evaluated satisfactory and reliable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
Embryotoxic and teratogenic effects of CTAB, a cationic surfactant, in the mouse
Author:
B. Isomaa and K. Ekman
Year:
1975
Bibliographic source:
Fd Cosmet. Toxicol. Vol 13 pp 331-334

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
CTAB in aqueous solution was given in single ip injections to four groups each of eight mice. The median lethal dose and its standard error were estimated according to Miller & Tainter (1994)*.
*: Miller, L.C.. & Tainter, M.L. (1994). Estimation of the ED 50 and its error by means of logarithmic-probit graph paper. Proc. Soc. exp. Biol. Med. 57, 261.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Cetyl trimethylammonium bromide (CTAB)
IUPAC Name:
Cetyl trimethylammonium bromide (CTAB)
Test material form:
not specified

Test animals

Species:
mouse
Strain:
NMRI
Sex:
female
Details on test animals or test system and environmental conditions:
The animals were given commercial pellets and water ad. lib. and maintained in a 12 hour light-dark sequence under ambient conditions of 20± 1°C and 60 ± 5% humidity.

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: aqueous solution
Details on exposure:
Single ip injections
Doses:
no data
No. of animals per sex per dose:
Four groups each of eight mice
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 85 - <= 127 mg/kg bw
Based on:
not specified
Mortality:
Death occured generally within 12 hr of administration. The animals that did not die recovered within 24 hr, although some delayed deaths did occur.
Clinical signs:
convulsions and respiratory depression

Applicant's summary and conclusion

Conclusions:
The acute ip LD50 for female mice was found to be 106±20 mg/kg bw.
Executive summary:

The acute ip LD50 for female mice was found to be 106±20 mg/kg bw.