Registration Dossier

Categories

Categories

Category name:
Pyridine and Pyridine Derivatives

Justifications and discussions

Category definition:
The category of pyridine and methyl-pyridine derivatives is established based on structural similarity and similar properties including toxicological behaviour.
Category description:
Pyridine is the sentinel substance, with the methyl derivatives as members with no specific order.
Category rationale:
A category of pyridine and alkyl pyridine derivatives is comprised of: pyridine (CASRN 110-86-1), 2-picoline (CASRN 109-06-8), 3-picoline (CASRN 108-99-6), and 4-picoline (CASRN 108-89-4). The basis of the category is structural similarity (based on the pyridine unsaturated ring structure) and similar physical properties, environmental fate and toxicity, and mammalian toxicity. Similar toxicological properties derive from common pathways of metabolism and elimination among all members of the category. The U.S. Environmental Protection Agency has accepted this category, as indicated in its September 2009 Hazard Characterization Document reviewing the screening-level data set submitted by an industry consortium under the voluntary High Production Volume (HPV) Challenge Program.