Glycine hydrochloride

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Link to relevant study record(s)

Reference

Endpoint:

relative self-ignition temperature (solids)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-03-08

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.16 (Relative Self-Ignition Temperature for Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Remarks on result:

no self-ignition observed up to the melting point

Findings

Table 1: Weight of cube

Weight (cube empty)	Weight (cube + Test Item)
3.7471 g	9.0238 g

Temperature Data

The temperatures which were measured in the experiment are presented in the following table.As many values were recorded, only the values every 60 minutes (until the oven had reached the chosen temperature) are presented.

Table 2: Presentation of Temperatures versus Time

Time in min	Temperature (test item) in °C	Temperature (oven) in °C
5	21.7	21.1
60	35.7	46.9
120	64.6	82.1
180	96.6	117.0
240	127.8	154.0
290	153.9	184.1

Determination of heating rate

The heating rate was calculated using the following equation:

Heating rate = (T2 -T1) / (t2 -t1)

T1 = Temperature after 5 minutes in °C

T2 = End temperature in °C

t1 = 5 min

t2 = time at which the end temperature was reached in min.

Table 3: Presentation of result heating rate

T1 in °C	21.1
t1 in min	5
T2 in °C	184.1
t2 in min	290
Heating rate in °C/min.	0.5719

No increase in the temperature of the sample in comparison to that of the oven could be detected; also no signs of ignition could be observed. The test item is considered as showing no self-ignition up to the melting range of 173 – 177 °C under the test conditions. No observations were made which might cause doubts concerning the validity of the study outcome.

Conclusions:

The test item was determined to be not self-igniting up to the melting range of 173 - 177 °C under the test conditions.

Executive summary:

A study was conducted according to Commission Regulation (EC) No. 440/2008 method A.16 in order to determine the self-ignition temperature of the test item by using the oven ZPA3. The test item was filled into a cube and placed into the temperature-programmed laboratory oven (ZPA3, Petrotest). The oven was heated from 21.1 °C to 182 °C. The final oven temperature was chosen under consideration of the melting range of 173 - 177 °C. While heating of the oven with a heating rate of 0.57 K/min the temperatures of the test item and the oven were printed every 5 minutes. No increase of the test item temperature in comparision to that of the oven was detected and no signs of self-ignition could be observed. Hence, the test item was considered to be not self-igniting up to the melting range of 173 - 177 °C under the test conditions.

Description of key information

The test item was determined to be not self-igniting up to the melting range of 173 - 177 °C under the test conditions.

Additional information

A study was conducted according to Commission Regulation (EC) No. 440/2008 method A.16 in order to determine the self-ignition temperature of the test item by using the oven ZPA3.The test item was filled into a cube and placed into the temperature-programmed laboratory oven (ZPA3, Petrotest). The oven was heated from 21.1 °C to 182 °C. The final oven temperature was chosen under consideration of the melting range of 173 - 177 °C. While heating of the oven with a heating rate of 0.57 K/min the temperatures of the test item and the oven were printed every 5 minutes. No increase of the test item temperature in comparision to that of the oven was detected and no signs of self-ignition could be observed. Hence, the test item was considered to be not self-igniting up to the melting range of 173 - 177 °C under the test conditions (reference 4.12-1).