1-Octanamine, N,N-dimethyl-, N-oxide

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 1st, 2007 - July 09th, 2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

yes

Remarks:

The surface tension results was not corrected using the Harkins-Jordan correction table as the correction is not applicable to the apparatus used. This deviation has been considered not to have affected the integrity of the study.

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Specific details on test material used for the study:

- Analytical purity: 82.3%
- Purity test date: Not available
- Lot/batch No.: GN-8
- Expiration date of the lot/batch: Not available
- Appearance: Amber coloured, extremely viscous liquid
- Storage: In the dark at room temperature
- Additional information on test material used for the study: It was attempted to purify the substance to a purity of >80% by using an alternative synthetic route, as opposed to the usual commercial route of synthesis which results in a purity of the substance of approximately 40% in water. This alternative synthetic route generated the substance at 82.3% purity, however it also generated an impurity (methanol at 4.0%) which is not present in the commercial substance. Based on the classification and labelling of methanol, it is considered that this additional impurity would not have an influence on any of the endpoints discussed in this dossier other than the acute oral toxicity study. Therefore all studies (including the one covering this endpoint) contained in this dossier (other than the acute oral toxicity study) were conducted on the 82.3% pure substance containing the 4.0% methanol impurity. The acute oral toxicity study has been conducted on the commercially generated substance at a purity of approximately 40% in water.

Key result

Surface tension:

44.8 mN/m

Temp.:

24.5 °C

Conc.:

1.21 g/L

Remarks on result:

other: mean corrected value

Remarks:

calibration factor = 1.007

Surface tension:

44.5 mN/m

Temp.:

24.5 °C

Conc.:

1.21 g/L

Remarks on result:

other: mean measured value

Calibration factor φ Reading (mN/m) Temperature (°C) Literature Value (mN/m) Calibration Factor 71.5 24.6 72.01 1.007 71.5 24.6 72.01 1.007 71.5 24.6 72.01 1.007 71.5 24.6 72.01 1.007 71.5 24.6 72.01 1.007 71.5 24.6 72.01 1.007 Mean Calibration Factor = 1.007 Sample solution readings Time (mins) Reading (mN/m) Temperature (°C) 165 44.5 24.6 175 44.5 24.6 185 44.5 24.6 205 44.5 24.6 215 44.5 24.6 Mean reading: 44.5mN/m Surface tension = reading x calibration factor = 44.5 x 1.007 = 44.8 mN/m Temperature: 24.5 ± 0.5°C pH of sample solution: 6.2

Conclusions:

The surface tension of a 1.21 g/L solution of the test material was determined to be 44.8 mN/m at 24.5 ± 0.5°C. The test material is therefore considered surface active.

Executive summary:

The surface tension of the test material was measured in a GLP-compliant study performed in accordance with EU Method A.5, using the ring method. The surface tension of a 1.21 g/L solution of the test material was determined to be 44.8 mN/m at 24.5 ± 0.5°C. The test material is therefore considered surface active.

Description of key information

The surface tension of the test material was measured in a GLP-compliant study performed in accordance with EU Method A.5, using the ring method. The surface tension of a 1.21 g/L solution of the test material was determined to be 44.8 mN/m at 24.5 ± 0.5°C. The test material is therefore considered surface active.

Key value for chemical safety assessment

Surface tension:

44.8

in mN/m at 20°C and concentration in mg/L:

1 210

Additional information

The surface tension of the test material was determined in a GLP-compliant study performed in accordance with standard methods, with minor deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.