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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental Starting Date: 21 April 2015 Experimental Completion Date: 08 June 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Remarks:
EXAMPLE: The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Key result
Water solubility:
0.267 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 5.68 - <= 6.11

Results

Preliminary Test

The preliminary estimate of water solubility was 0.256 g/L at 20 °C.

Please see Attachment 1 for the Typical Chromatography.

The mean peak areas relating to the standard and sample solutions are shown in the following table:

 

Table 3.7

 

Solution

Mean Peak Area

Standard at 50.6 mg/L

2.0902 x 107

Standard at 51.6 mg/L

2.1284 x 107

Matrix Blank

None detected

Sample 1A

2.1368 x 107

Sample 1B

2.1371 x 107

Sample 2A

2.2379 x 107

Sample 2B

2.2347 x 107

Sample 3A

2.2445 x 107

Sample 3B

2.2508 x 107

 

The concentration (g/L) of test item in the sample solutions is shown in the following table:

 

Table 3.8

 

Sample Number

Time Shaken at

~30 ºC (h)

Time Equilibrated at 20 ºC (h)

Concentration (g/L)

Solution pH

1

24

24

0.259

5.68

2

48

24

0.271

6.09

3

72

24

0.272

6.11

 

Overall concentration :          0.267 g/L at 20.0 ± 0.5 ºC

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 5 to 100 mg/L. This was satisfactory with a goodness of fit of 1.000 being obtained.

Conclusions:
The water solubility of the test item has been determined to be 0.267 g/L at 20.0 ± 0.5 °C.
Executive summary:

The determination was carried out using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

The test system consists of purified water with a resistivity of greater than 15MΩ.

Conclusion

The water solubility of the test item has been determined to be 0.267 g/L at 20.0 ± 0.5 °C.

Description of key information

The water solubility of the substance has been determined to be 0.267 g/L at 20.0 °C.

The pH of the aqueous samples was 5.7 - 6.1.

Key value for chemical safety assessment

Water solubility:
0.267 g/L
at the temperature of:
20 °C

Additional information