2-isopropoxyethyl salicylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental Starting Date: 21 April 2015 Experimental Completion Date: 08 June 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Remarks:

EXAMPLE: The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.

Key result

Water solubility:

0.267 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 5.68 - <= 6.11

Results

Preliminary Test

The preliminary estimate of water solubility was 0.256 g/L at 20 °C.

Please see Attachment 1 for the Typical Chromatography.

The mean peak areas relating to the standard and sample solutions are shown in the following table:

 

Table 3.7

 

Solution		Mean Peak Area
Standard at 50.6 mg/L		2.0902 x 10^7
Standard at 51.6 mg/L		2.1284 x 10^7
Matrix Blank		None detected
Sample 1A		2.1368 x 10^7
Sample 1B		2.1371 x 10^7
Sample 2A		2.2379 x 10^7
Sample 2B		2.2347 x 10^7
Sample 3A		2.2445 x 10^7
Sample 3B		2.2508 x 10^7

 

The concentration (g/L) of test item in the sample solutions is shown in the following table:

 

Table 3.8

 

Sample Number	Time Shaken at ~30 ºC (h)	Time Equilibrated at 20 ºC (h)	Concentration (g/L)	Solution pH
1	24	24	0.259	5.68
2	48	24	0.271	6.09
3	72	24	0.272	6.11

 

Overall concentration :          0.267 g/L at 20.0 ± 0.5 ºC

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 5 to 100 mg/L. This was satisfactory with a goodness of fit of 1.000 being obtained.

Conclusions:

The water solubility of the test item has been determined to be 0.267 g/L at 20.0 ± 0.5 °C.

Executive summary:

The determination was carried out using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

The test system consists of purified water with a resistivity of greater than 15MΩ.

Conclusion

The water solubility of the test item has been determined to be 0.267 g/L at 20.0 ± 0.5 °C.

Description of key information

The water solubility of the substance has been determined to be 0.267 g/L at 20.0 °C.

The pH of the aqueous samples was 5.7 - 6.1.

Key value for chemical safety assessment

Water solubility:

0.267 g/L

at the temperature of:

20 °C