Registration Dossier
Registration Dossier
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EC number: 222-248-0 | CAS number: 3396-11-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
According to the Endpoint specific Guidance (Chapter R.7a, version 4.1, October 2015) bacterial mutagenesis assays of inorganic metal compounds are frequently negative due to limited capacity for uptake of metal ions and/or the induction of large DNA deletions by metals in bacteria potentially leading to an increased death rate in mutants. The high prevalence of false negatives for metal compounds might suggest that mutagenesis assays with mammalian cells, as opposed to bacterial cells, would be the preferred starting point for testing for this class of Annex VII substances. Therefore, mutagenicity data in mammalian cells is provided instead.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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