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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of test chemical in rat
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
secondary source
Title:
Acute oral toxicity study of test chemical in rat
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of test chemical was performed in rats.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride
EC Number:
222-887-5
EC Name:
2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride
Cas Number:
3648-36-0
Molecular formula:
C22H26ClN2.Cl
IUPAC Name:
2-(2-{4-[(2-chloroethyl)(methyl)amino]phenyl}vinyl)-1,3,3-trimethyl-3H-indolium chloride
Details on test material:
- Name of test material (IUPAC name): 2-(2-{4-[(2-chloroethyl)(methyl)amino]phenyl}vinyl)-1,3,3-trimethyl-3H-indolium chloride- Common name: Astrazone pink FG- Molecular formula: C22H26ClN2.Cl- Molecular weight: 389.367 g/mol- Smiles notation: c12c([N+](C)=C(C1(C)C)\C=C\c1ccc(N(CCCl)C)cc1)cccc2.[ClH-]- InChl: 1S/C22H26ClN2.ClH/c1-22(2)19-7-5-6-8-20(19)25(4)21(22)14-11-17-9-12-18(13-10-17)24(3)16-15-23;/h5-14H,15-16H2,1-4H3;1H/q+1;/p-1- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (IUPAC name): 2-(2-{4-[(2-chloroethyl)(methyl)amino]phenyl}vinyl)-1,3,3-trimethyl-3H-indolium chloride- Common name: Astrazone pink FG- Molecular formula: C22H26ClN2.Cl- Molecular weight: 389.367 g/mol- Smiles notation: c12c([N+](C)=C(C1(C)C)\C=C\c1ccc(N(CCCl)C)cc1)cccc2.[ClH-]- InChl: 1S/C22H26ClN2.ClH/c1-22(2)19-7-5-6-8-20(19)25(4)21(22)14-11-17-9-12-18(13-10-17)24(3)16-15-23;/h5-14H,15-16H2,1-4H3;1H/q+1;/p-1- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2260 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
Details on study design :- Other examinations performed: clinical signs
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 260 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at dose 2260 mg/kg bw
Clinical signs:
In Clinical signs observation,changes in blood, change in blood or tissue levels( Transaminases) and Enzyme inhibition, induction were observed.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2260 mg/kg bw,when rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 2260 mg/kg bw.In Clinical signs observation,changes in blood,change in blood or tissue levels( Transaminases) and Enzyme inhibition, induction were observed.Hence,LD50 value was considered to be 2260 mg/kg bw,when rats were treated with test chemicalorally.