Registration Dossier
Registration Dossier
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EC number: 294-589-3 | CAS number: 91744-27-3
Endpoint summary
Administrative data
Description of key information
The substance is not considered to be irritating to the skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vivo skin irritation (OECD 404)
In a GLP compliant in vivo skin irritation study, performed according to OECD 404, 3 Kleinrussen Chbb:HM rabbits received a dermal application of the undiluted test substance. The animals were exposed for 4 hours under semi-occlusive conditions. Erythema and oedema were scored after 1, 24, 48 and 72 hours. The reversibility of the reactions was recorded for 7 days. The mean (24-72 h) erythema score was determined to be 0.66, 1.66, and 0 for animal 1, 2, and 3, respectively. The mean (24-72h) oedema score was determined to be 0, 1, and 0 for animal 1, 2, and 3, respectively. All observations were reversible within 7 days. Based on these observations, the substance was not considered to be irritating to the skin (Henkel, 1990).
In vivo eye irritation (OECD 405)
In a GLP compliant in vivo eye irritation study, performed according to OECD 405, 0.1 mL undiluted test substance was applied to the right eye of three Kleinrussen, Chbb:HM rabbits. Directly after application the eyelids were shortly closed. After an exposure period of 24 hours, the eye was thoroughly washed with warm water to terminate the exposure. The left eye served as a negative (untreated) control. Reactions were scored after 1, 24, 48 and 72 hours and 7 and 14 days. At the 24 hour and 7 day timepoints, the eye was treated with fluorescein and examined by means of a split lamp. In one animal a very slight corneal lesion was observed. Based on the fluorescein staining on day 14 however, a substance specific effect could be excluded. Other effects were limited to exudation (1 hour after treatment in all animals) and chemosis (only 1 hour after treatment in 1 animal). The average cornea score (24-72h) was determined to be 1 for 1 animal. For other 2 animals this score was determined to be 0. All other average (24-72 h) scores (iris, conjunctivae, chemosis) were determined to be 0 for all animals. Based on these data, the substance is not considered to be an eye irritant (Henkel, 1990).
Justification for classification or non-classification
Based on the available data classification and labelling for skin and eye irritation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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