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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1972
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report Date:
1972

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Name of the test substance used in the study report: Neozaponschwarz RE
Appearance: Solid
Substance number: 65-4710

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE
- Rate of air: 200 L/ hour
- Atmosphere is saturated with a vapour which is generated at 200 °C
Duration of exposure:
8 h
Concentrations:
mean concentration: 1.58 mg/L
No. of animals per sex per dose:
12 and 6 control animals
Control animals:
other: air control
Details on study design:
- Duration of observation period following administration: 1 week
- Frequency of observations: 3, 10 and 30 min, 1, 3 and 8 hours
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Remarks on result:
not determinable
Remarks:
Study discontinued due to technical problems that caused all animals to die.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification