Registration Dossier
Registration Dossier
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EC number: 296-117-1 | CAS number: 92257-28-8
Endpoint summary
Administrative data
Link to relevant study record(s)
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
The Annex VIII of the REACH regulation requires an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information.
Key value for chemical safety assessment
Additional information
The Annex VIII of the REACH regulation requires an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information. There is no available data on the toxicokinetics of the chemical 2-Naphthalenamine, N-(2-ethylhexyl)-1-[[4-(phenylazo)phenyl]azo]-, ar’ and ar’’-Me derivs (CAS No. 92257-28-8). Toxicokinetics is essentially the study of "how a substance gets into the body and what happens to it in the body". Four processes are involved in toxicokinetics; namely absorption, distribution, metabolism and excretion (ADME). It may be noted that the chemical 2-Naphthalenamine, N-(2-ethylhexyl)-1-[[4-(phenylazo)phenyl]azo]-, ar’ and ar’’-Me derivs (CAS No. 92257-28-8)is a dark red clear liquid r having applications such as use in Colorant for petroleum products and dyeing. Since the chemical is not a food dye, it is unlikely to be ingested and there is a low possibility of the chemical exerting a toxic effect after ingestion. The chemical is expected to have low potential for absorption across biological membranes due to the very low solubility in water and corresponding high partition coefficient value of Log Pow = 8.2101. As per the Lipinski rule, chemical having Log Pow greater than 3 are not readily bioavailable. Thus, these chemicals even if ingested are expected to be excreted out of the human body unchanged. Thus, the likelihood of inhalation of these particles is low. Thus, considerign the use of this chemical as well as the fact that oral and inhalation exposure are very unlikely, the end point of toxico-kinetics was considered for waiver.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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