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Administrative data

Description of key information

LD50 (oral, rat) > 5000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Acute oral toxicity

The substance was administered by gavage to a group of male rats at a dose level of 5000 mg/kg.

The LD50 (rat, oral) was found to be greater than 5000 mg/kg bw.

 

In addition, an acute dermal toxicity data is available and a LD50 greater than 5000 mg/kg bw obtained after a 4-hour exposure is indicated. However, no details concerning the method folled are available.

Justification for classification or non-classification

In the CLP Regulation (EC) no. 1272/2008 acute toxicity is defined as “those adverse effects occurring following oral or dermal administration of a single dose of a substance or a mixture, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours”. A substance can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route. The numeric criteria based on the acute toxicity estimates (ATE) in mg/kg bodyweight are presented in Annex I, Part 3, Table 3.1.1. For acute oral toxicity: "Category 4: 300 < ATE ≤ 2 000".

Based on the available experimental data of acute oral toxicity (LD50 > 5000 mg/kg bw), no classification for acute oral toxicity is warranted under the CLP Regulation (EC) no.1272/2008.