Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-611-2 | CAS number: 108-73-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- CAS 108-73-6 OECD Toolbox v3.4.0 experimental data for an Ames test and for in vitro chromosome aberration in Chinese hamster lung cells, and for a micronucleus test
- Author:
- Japan Ministry of Health, Labour and Wellfare
- Year:
- 2 018
- Bibliographic source:
- OECD Toolbox v3.4.0
- Report date:
- 2018
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Remarks:
- the actual study was performed before 2008
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Phloroglucinol
- EC Number:
- 203-611-2
- EC Name:
- Phloroglucinol
- Cas Number:
- 108-73-6
- Molecular formula:
- C6H6O3
- IUPAC Name:
- benzene-1,3,5-triol
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- other: S. typhimurium TA 97/98/100/1535/1537
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- other: S. Typhimurium TA 97/98/100/1535/1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Key result
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
