Registration Dossier
Registration Dossier
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EC number: 203-611-2 | CAS number: 108-73-6
Endpoint summary
Administrative data
Description of key information
At the tested dose of 300 mg/kg bw/day (rat, oral, gavage) no toxic effects were observed. See also the attached EMEA summary report for supportive information regarding a study in which dogs were treated for 6 months (oral). No toxic effects were observed at even the maximum dose of 125 mg/kg bw/day.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 300 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
At the effect level found there is no requirement for classification as STOT RE
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