Registration Dossier
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EC number: 201-473-8 | CAS number: 83-40-9
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: scanning electron microscopy after the sample was fractionated by a 100 μm sieve
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- Hydroxytoluic acid
- EC Number:
- 201-473-8
- EC Name:
- Hydroxytoluic acid
- Cas Number:
- 83-40-9
- Molecular formula:
- C8H8O3
- IUPAC Name:
- hydroxytoluic acid
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 14.44 µm
- Remarks on result:
- other: as spherical particles (Sieve Fraction nominal < 100μm)
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 4 µm
- Distribution:
- 0 %
- Remarks on result:
- other: respirable fraction; accounting based on the total sample weight
- No.:
- #2
- Size:
- >= 4 - < 10 µm
- Distribution:
- 0.04 %
- Remarks on result:
- other: thoracic fraction; accounting based on the total sample weight
- No.:
- #3
- Size:
- >= 10 - < 100 µm
- Distribution:
- 2.16 %
- Remarks on result:
- other: inhalable fraction; accounting based on the total sample weight
Applicant's summary and conclusion
- Conclusions:
- Particle size distribution was determined according to OECD 110 (GLP), so there is no reason to conclude that the results are not reliable. The study was assessed to be of high quality and testing is expected to be reasonably performed; results can be considered as reliable. The substance contains 0 % respirable particles (< 4 µm), 0.04 % thoracic particles (4-10 µm) and 2.16 % inhalable particles (10-100 µm).
- Executive summary:
The particle size distribution of the test substance was determined by scanning electron microscopy after the samples was fractionated by a 100 μm sieve according to OECD Guideline 110 (GLP).
Sieve Fraction
weighted sample: 0.8451 g
weight fraction < 100 μm: 0.0186 g
sieve mass fraction < 100 μm: 2.20 %
Mass Fraction
Sieve Fraction nominal < 100μm
Particle Size Spherical Volume Cubical volume < 4 µm (respirable) 0.00 % 0.00 % 4 -10 µm (thoracic) 1.97 % 2.42 % 10 -100 µm (inhalable) 98.03 % 97.58 % > 100 µm 0.0 % 0.0 % Median (diameter) 14.44 µm 13.45 µm Median diameter corresponds to MMAD (Mass Median Aerodynamic Diameter < 100μm).
Accounting based on the total sample weight:
Particle Size [µm] Spherical Volume [%] Mass Fraction > 100 97.80 Sieve Fraction > 100 0.00 Total (> 100 µm) 97.80 Sieve Fraction 10 -100 (inhalable) 2.16 Sieve Fraction 4 -10 (thoracic) 0.04 Sieve Fraction < 4 (respirable) 0.00 Median diameter corresponds to MMAD (Mass Median Aerodynamic Diameter < 100μm).
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