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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Isonicotinonitrile
EC Number:
202-856-2
EC Name:
Isonicotinonitrile
Cas Number:
100-48-1
Molecular formula:
C6H4N2
IUPAC Name:
pyridine-4-carbonitrile
Specific details on test material used for the study:
98% minimum on dry basis

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
Four groups of four albino rabbits (2 M, 2 F) weighing between 2.0 and 3.0 kg, each were employed in this study. All animals had their backs clipped free of hair 24 hours prior to testing. All of the animals had their backs abraded prior to dosing.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
All animals weighed and correct amount of experimental material applied to the back of each animal. Treated areas covered with large gauze patches and impervious material wrapped snugly around the trunk of each animal. Dressings were removed and approximate amount remaining was noted. Animals observed for 14 day period for signs of toxicity and for mortaility. Gross autopsies performed on all animals which died during 14-day observation period and also on all survivors of 14-day observation period.
Duration of exposure:
not specified
Doses:
4.0, 8.0, 16.0, 20.0 grams/kg
No. of animals per sex per dose:
2 males/2 females
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
20 000 mg/kg bw
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
16 000 mg/kg bw
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
8 000 mg/kg bw
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
4 000 mg/kg bw
Mortality:
0/4 for all dose groups
Clinical signs:
other: At 4000 and 8000 mg/kg, no untoward symptoms noted. At 16,000 mg/kg and 20,000 mg/kg, animals were depressed and had diarrhea for up to 48 hours.
Gross pathology:
Gross pathologic examination revealed nothing remarkable.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Dermal LD50 for 4-Cyanopyridine is greater than 20,000 mg/kg in rabbits.
Executive summary:

Dermal LD50 for 4-Cyanopyridine is greater than 20,000 mg/kg in rabbits.