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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
other: Endpoint Expert Assessment
Adequacy of study:
key study
Study period:
March 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
other: Endpoint Expert Assessment
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
An assessment was performed based on structures, molecular weights and toxicokinetics of the substance using the OECD QSAR Toolbox v4.2 to predict the skin sensitisation potential of Aryl sulphonate condensate.
GLP compliance:
no
Type of study:
other: An assessment was performed based on structures, molecular weights and toxicokinetics of the substance using the OECD QSAR Toolbox v4.2 to predict the skin sensitisation potential of Aryl sulphonate condensate.

Test material

Constituent 1
Chemical structure
Reference substance name:
Diammonium 1,1'-methylenebis[(phenylmethyl)naphthalene-2-sulphonate]
EC Number:
284-353-8
EC Name:
Diammonium 1,1'-methylenebis[(phenylmethyl)naphthalene-2-sulphonate]
Cas Number:
84852-41-5
Molecular formula:
C35H38N2O6S2.2H3N
IUPAC Name:
Diammonium 1,1'-methylenebis((phenylmethyl)naphthalene-2-sulphonate)
Constituent 2
Chemical structure
Reference substance name:
Benzyl methylene-bis-napthalene-2-sulphonic acid ammonium salt
IUPAC Name:
Benzyl methylene-bis-napthalene-2-sulphonic acid ammonium salt
Constituent 3
Reference substance name:
Isomers of Benzyl methylene-bis-naphthalene trisulphonic acid ammonium salt
Molecular formula:
Not applicable
IUPAC Name:
Isomers of Benzyl methylene-bis-naphthalene trisulphonic acid ammonium salt
Constituent 4
Chemical structure
Reference substance name:
Ammonium sulphate
EC Number:
231-984-1
EC Name:
Ammonium sulphate
Cas Number:
7783-20-2
Molecular formula:
(NH4)2SO4
IUPAC Name:
diammonium sulfate
Constituent 5
Reference substance name:
Unidentified isomers formed during the reaction
Molecular formula:
Not applicable
IUPAC Name:
Unidentified isomers formed during the reaction
Constituent 6
Chemical structure
Reference substance name:
Formaldehyde
EC Number:
200-001-8
EC Name:
Formaldehyde
Cas Number:
50-00-0
Molecular formula:
C H2 O
IUPAC Name:
formaldehyde
Test material form:
solid

Results and discussion

In vitro / in chemico

Results
Key result
Remarks on result:
other: Quantitative results were not determined as no test was performed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
An assessment of the potential for the constituents to induce skin sensitisation concluded that Aryl sulphonate condensate is not expected to meet the criteria for classification in accordance with Regulation (EC) 1272/2008.
Executive summary:

The potential of Aryl sulphonate condensate to induce skin sensitisation is expected to be driven by the capacity of its constituents to induce skin sensitisation. Based on a (Q)SAR assessment of the main constituents, no sensitisation is expected. The substance contains formaldehyde (CAS 50-00-0) a known skin sensitiser as a minor constituent <0.15 %w/w, however this is below the threshold for classification set in CLP Regulation (EC) 1272/2008, Annex I, 3.4.