Registration Dossier
Registration Dossier
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EC number: 435-780-5 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 March 1999 to 4 June 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- < 0.207 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 6.9
- Details on results:
- The preliminary test indicated that the column elution method should have been performed as the solubility was less than 0.01 mg/L. However, due to the physical nature of the test material, it was not possible to use this method; experience has shown that liquid test materials coated onto glass beads cause these beads to adhere together forming a plug within the column and thus preventing water circulation.
- Conclusions:
- The water solubility of the substance was found to be < 0.207 mg/L at 20 ± 0.5 °C.
- Executive summary:
The water solubility of the test material was investigated in a study which was conducted under GLP conditions and in accordance with the standardised guideline EU Method A.6, following the shake flask method.
Under the conditions of the study, the water solubility of the substance was found to be < 0.207 mg/L at 20 °C.
The result given is a limit value which is below the limit of detection of the analytical method.
Reference
Description of key information
Water solubility = < 0.207 mg/L at 20 °C, EU Method A.6 (Shake Flask Method), Woolley & Mullee (1999)
Key value for chemical safety assessment
Additional information
The water solubility of the test material was investigated in a study which was conducted under GLP conditions and in accordance with the standardised guideline EU Method A.6, following the shake flask method.
Under the conditions of the study, the water solubility of the substance was found to be < 0.207 mg/L at 20 °C.
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