Registration Dossier
Registration Dossier
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EC number: 231-832-4 | CAS number: 7758-09-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from handbook.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity study of test chemical
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials
- Reference Type:
- other: authoritative database.
- Title:
- Acute oral toxicity - test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity -- Test chemical
- Author:
- Michael Ash
- Year:
- 2 004
- Bibliographic source:
- Handbook of Preservatives
- Reference Type:
- review article or handbook
- Title:
- Acute Oral Toxicity study of the test chemical
- Author:
- Bernard Martel
- Year:
- 2 000
- Bibliographic source:
- Chemical Risk Analysis: A Practical Handbook
- Reference Type:
- other: Secondary Literature
- Title:
- Acute toxicity summary of the test chemical
- Author:
- GSBL
- Year:
- 2 017
- Bibliographic source:
- GSBL
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- To determine the acute oral LD50 of the test chemical in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Potassium nitrite
- EC Number:
- 231-832-4
- EC Name:
- Potassium nitrite
- Cas Number:
- 7758-09-0
- Molecular formula:
- HNO2.K
- IUPAC Name:
- potassium nitrite
- Test material form:
- solid
- Details on test material:
- - IUPAC Name: Potassium nitrite
- InChI: 1S/K.HNO2/c;2-1-3/h;(H,2,3)/q+1;/p-1
- Smiles: N(=O)[O-].[K+]
- Molecular formula :KNO2
- Molecular weight:85.103 g/mol
- Substance type:Inorganic
- Physical state:Solid, white or slightly yellowish
Constituent 1
- Specific details on test material used for the study:
- Molecular formula :KNO2
- Molecular weight:85.103 g/mol
- Substance type:Inorganic
- Physical state:Solid, white or slightly yellowish
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- 50% mortality was observed. The acute oral LD50 value was considered to be 200 mg/kg, when rabbits were treated with the test chemical via oral route.
- Executive summary:
Acute oral toxicity study of the test chemical was conducted in rabbits. The test chemical at the dose concentration of 200 mg/kg bw was given orally to the test animals and observed for mortality. 50% mortality was observed. The acute oral LD50 value was considered to be 200 mg/kg, when rabbits were treated with the test chemical via oral route.
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