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EC number: 947-360-3 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72 h EL50 (growth rate and yield) and the NOEC for the test substance to algae was determined to be >100% and 100% SS (prepared at a loading rate of 100 mg/L) respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
A study was conducted to determine the toxicity of the test substance, mono- and di- C12-18 PSE, Na+, to aquatic algae and cyanobacteria according to OECD Guideline 201 and EU Method C.3, in compliance with GLP. A combined limit/range-finding test was performed, exposing six replicates of exponentially growing algal cultures (Pseudokirchneriella subcapitata) to a control (medium alone) and to 1.0, 10 and 100% of the saturated concentration/solution (SS), acheived at a loading rate of 100 mg/L. The initial algal cell density was 10E4 cells/mL and the total exposure period was 72 h under static conditions. Growth rate and yield were recorded throughout the study. Due to the complex nature of the test substance, specific analyses proved to be difficult to obtain; hence Total Organic Carbon (TOC) concentrations were analysed as a surrogate measure. Samples for TOC concentrations were taken at the start and after 24 and 72 h of exposure. The TOC analysis performed on samples taken from 100% of the SS were to be regarded as indicative because of the low carbon concentrations. The effect parameters were based on the percentages of the SS prepared at a loading rate of 100 mg/L. No significant differences were recorded between the values for growth rate or yield at the highest concentration tested when compared to the control group. Microscopic observations at the end of the test revealed a normal and healthy appearance of the algal cells exposed to the highest test concentration when compared to the control. The study met the acceptability criteria prescribed by the study plan and was considered valid. Under the conditions of the study, the 72 h-EL50 for inhibition of both growth rate (ErL50) and yield (EyL50) was considered to be above 100% and the 72 h-NOELR for inhibition of both growth rate and yield inhibition was also considered at 100% of SS, which was prepared at a loading rate of 100 mg/L (Bouwman, 2017).
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