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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
adult fish: sub(lethal) effects
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar toxicological properties because
• they are manufactured from similar or identical precursors under similar conditions
• they share structural similarities with common functional groups: D-Glucopyranose monomers and oligomers and fatty alcohols C8 to C18 linear
• the metabolism pathway leads to comparable products (Glucose and glucose oligomers) and non-common products predicted to have no toxicological effects (long chain fatty alcohols).

Therefore, read-across from the existing acute toxicity studies on the source substances is considered as an appropriate adaptation to the standard information requirements of REACH regulation

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The target substance D-Glucose, reaction products with alcohols C16-18 (even numbered) and the source substance D-Glucopyranose, oligomeric, C10-16-alkyl glycosides differ only in respect to the alkyl chain length with the source substance containing predominantely shorter C-chains.

3. ANALOGUE APPROACH JUSTIFICATION
see attached justification

4. DATA MATRIX
see attached justification

Justification attached in chap. 13
Reason / purpose for cross-reference:
read-across source
Key result
Dose descriptor:
NOEC
Effect conc.:
> 1 - < 1.8 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
act. ingr.
Basis for effect:
other: condition
Remarks on result:
other: base for the lower effect concentration: condition; base for the higher effect conc.: mortality

Description of key information

After 28 days the NOEC was in between 1 mg a.i./L (endpoint: condition) and 1.8 mg a.i./L (endpoint: mortality).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 mg/L

Additional information