Registration Dossier
Registration Dossier
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EC number: 947-427-7 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar toxicological properties because
• they are manufactured from similar or identical precursors under similar conditions
• they share structural similarities with common functional groups: D-Glucopyranose monomers and oligomers and fatty alcohols C8 to C18 linear
• the metabolism pathway leads to comparable products (Glucose and glucose oligomers) and non-common products predicted to have no toxicological effects (long chain fatty alcohols).
Therefore, read-across from the existing acute toxicity studies on the source substances is considered as an appropriate adaptation to the standard information requirements of REACH regulation
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The target substance D-Glucose, reaction products with alcohols C16-18 (even numbered) and the source substance D-Glucopyranose, oligomeric, C10-16-alkyl glycosides differ only in respect to the alkyl chain length with the source substance containing predominantely shorter C-chains.
3. ANALOGUE APPROACH JUSTIFICATION
see attached justification
4. DATA MATRIX
see attached justification
Justification attached in chap. 13 - Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOEC
- Effect conc.:
- > 1 - < 1.8 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: condition
- Remarks on result:
- other: base for the lower effect concentration: condition; base for the higher effect conc.: mortality
Reference
Description of key information
After 28 days the NOEC was in between 1 mg a.i./L (endpoint: condition) and 1.8 mg a.i./L (endpoint: mortality).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
