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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
other: literature review
Adequacy of study:
key study
Reliability:
other: not applicable

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
Nicotine absorption is highly depended on pH. Pharmacokinetics and pharmacodynamics are influenced by several variables. These are for example how efficient nicotine is metabolised, how rapidly it is up taken, which physiological effects do influence nicotine metabolism and how nicotine is excreted. The major route for nicotine uptake in nicotine-bitartrate is the oral cavity. Oral or i.p. administrations are limited by first-pass metabolism. These effects must be considered on the relative dose exposure to nicotine. Half-life of nicotine in rodents is shorter than in humans/primates. Therefore, higher daily doses of nicotine are necessary in rodent models to achieve nicotine concentrations which are comparable to those seen in smokers.

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