Registration Dossier
Registration Dossier
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EC number: 500-258-9 | CAS number: 74775-06-7 1 - 2.5 moles propoxylated
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- other: Endpoint Assessment Report
- Adequacy of study:
- key study
- Study period:
- March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- other: Endpoint Assessment Report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
- Reference Type:
- publication
- Title:
- An evaluation of the safety of PPG-2 myristyl ether propionate.
- Author:
- Bernard BK, Harris JE, Fischer JE.
- Year:
- 1 998
- Bibliographic source:
- Food Additives & Contaminants. May-Jun;15(4):427-36.
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An extensive literature search was undertaken to identify studies on the toxicity to repsrotduction of PPG-2 myristyl ether propionate.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(1-tetradecoxypropan-2-yloxy)propan-2-yl propanoate (2 mol PO)
- Molecular formula:
- C23H46O4
- IUPAC Name:
- 1-(1-tetradecoxypropan-2-yloxy)propan-2-yl propanoate (2 mol PO)
- Reference substance name:
- 1-(1-tetradecoxypropan-2-yloxy)propan-2-yl propanoate (1 mol PO)
- Molecular formula:
- C23H46O4
- IUPAC Name:
- 1-(1-tetradecoxypropan-2-yloxy)propan-2-yl propanoate (1 mol PO)
- Reference substance name:
- Tetradecyl propionate
- EC Number:
- 228-300-9
- EC Name:
- Tetradecyl propionate
- Cas Number:
- 6221-95-0
- Molecular formula:
- C17H34O2
- IUPAC Name:
- tetradecyl propanoate
- Reference substance name:
- PG-2 Tetradecan-1-ol
- IUPAC Name:
- PG-2 Tetradecan-1-ol
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Key result
- Remarks on result:
- other: Quantative results not determined
Results: F1 generation
Effect levels (F1)
- Key result
- Remarks on result:
- other: Quantative results not determined
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- Based on the information available it can be concluded that the substance is not toxic to reproduction.
- Executive summary:
A reliable study performed by Bernard et al. (1998) was identified in the literature. This study included examination of the reproductive organs of treated animals allowing to investigate the effects of the substance to fertility. No lesions on reproductive organs were reported. No morphological effects attributable to test substance were observed during the microscopic examination.
It is concluded that PPG-2 myristyl ether propionate is not toxic to reproduction. This is supported by the historical uses of the substance is cosmetics and personal care products.
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