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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August from 08 to 16, 1991
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
according to guideline
EU Method A.6 (Water Solubility)
GLP compliance:
Type of method:
flask method
Water solubility:
194 g/L
Conc. based on:
test mat.
Incubation duration:
24 - 72 h
20 °C
Details on results:
The substance forms a high viscose solution at a concentration of 1000 g/l. Therefore it was not possible to use a five fold concentration for the determination of the water solubility, as required by the EU method A.6. Consequently, the solubility could be higher than the mean value found.

The results of the main test are showed in the table below.

1 2 3
Weight of the test substance (g) 11.027 11.614 11.406
Volume of water (ml) 5.0 5.0 5.0
Temperature during agitation (°C) 30 30 30
Agitation duration (hrs) 24 48 72
Temperature of equilibration (°C) 20 20 20
Equilibration duration (hrs) 24 24 24
pH of the solution at 20 °C
(after centrifugation)
4.8 4.8 4.8
Water solubility (g/l) 191.8 195.9 195.5
Mean value (g/l) 194
Water solubility: 194 g/l at 20 °C and pH 4.8
Executive summary:

The water solubility of the substance was assessed by the shake flask method, according to the EU Method A.6. The quantity of the substance to be tested was estimated in the preliminary test. Three stoppered flasks containing the right amount of the test material and water were agitated for 24, 48 and 72 hours respectively, at 30 °C. After 24 hours of equilibration (at 20 °C), the concentration of the substance on the supernatant was estimated spectrophotometrically.


The water solubility of the substance was found to be 194 g/l at 20 °C and pH 4.8.

Description of key information

194 g/l at 20 °C and pH 4.8

Key value for chemical safety assessment

Water solubility:
194 g/L
at the temperature of:
20 °C

Additional information

EU Method A.6 - flask method