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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1993-12-06 to 1994-04-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
1992
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
signed 1994-03-16
Type of method:
flask method
Key result
Water solubility:
148 mg/L
Conc. based on:
test mat.
Incubation duration:
>= 48 - <= 96 h
Temp.:
20 °C
pH:
>= 6.2 - <= 6.3
Remarks on result:
other: loading of aqueous phase: ~ 1 g/L

RESULTS

The preliminary test determined the water solubility to be approximately 0.18 g/L. The mean peak heights relating to the standard and sample solutions are detailed below:

Solution Mean peak height
Standard 1.00 x 10³ mg/L 2.082 x 105
Standard 1.01 x 10³ mg/L 1.979 x 105
Sample 1 1.488 x 105
Sample 2 1.497 x 105
Sample 3 1.489 x 105 

Sample number Time shaken at 30 °C [h] Time held at 20 °C [h] Concentration [g/L] Solution pH
1 24 24 0.147 6.3
2 48 24 0.148 6.2
3 72 24 0.147 6.3

Mean = 0.148 g/L

Range = 0.147 to 0.148 g/L

Conclusions:
According to Council Directive 92/69/EEC A.6, the water solubility of the test item is 148 mg/L (20 °C ± 0.5 °C, pH 6.3). The test substance is moderately soluble.

Description of key information

The water solubility of the test substance is 148 mg/L (20 °C ± 0.5 °C, pH 6.3).

Key value for chemical safety assessment

Water solubility:
148 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the substance was performed in accordance to Council Directive 92/69/EEC A.6 under GLP. Based on preliminary results the flask method was applied. The substance was analytically verified using GC.