Sodium 5-oxo-DL-prolinate

Density

Description of key information

The relative density of the test material was 1.55 at 21.2 ± 0.5 °C, EU Method A.3, Butler (2008). 

Key value for chemical safety assessment

Relative density at 20C:

1.55

Additional information

In the key study (Butler & White, 2008), the relative density of the test material was determined in a study conducted according to GLP and the standardised guideline EU Method A. 3., using the pycnometer method.

The instrument was calibrated prior to measurement of the test material. Aliquots of test material were weighed into the sample cell of known volume and placed into the pycnometer. Pressure readings were taken after pressurising the reference cell of known volume and then switching to the sample cell. The relative density was then calculated. The study was assigned a reliability score of 1 in line with the principles for assessing data quality as defined by Klimisch et al. (1997).

Under the conditions of the study, the test material was determined to have a relative density of 1.55 at 21.2 ± 0.5 °C.

The supporting study (Younis, 2012) was performed using information from the read across substance, sodium 5-oxo-L-prolinate, which is the L isomeric form of the substance. Read-across is considered to be suitable based on the structural similarities between the read across substance (sodium 5-oxo-L-prolinate) and the substance to be registered (sodium 5-oxo-DL-prolinate). As such the difference in isomeric forms of the substance is unlikely to affect the physico-chemical properties. The study was conducted under GLP conditions and in accordance with standardised guideline EU Method A. 3. The study was assigned a reliability score of 2 in line with the principles for assessing data quality as defined by Klimisch (1997).

Under the conditions of the study, the relative density was determined to be 1.57 (density 1570 kg/m³).