Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental period was 27 November 2017 to 29 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
7-hydroxy-N,N,N-trimethylnaphthalen-2-aminium methyl sulfate
Cas Number:
377734-55-9
Molecular formula:
C14H19NO5S
IUPAC Name:
7-hydroxy-N,N,N-trimethylnaphthalen-2-aminium methyl sulfate
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Batch: 16-09-01 (taken from label)
Purity/Composition: 100%
Test item storage: At room temperature
Stable under storage conditions until: 05 September 2019 (expiry date)

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
ca. 141.2 °C
Atm. press.:
ca. 1 atm
Decomposition:
yes
Decomp. temp.:
ca. 141.2 °C
Sublimation:
no

Any other information on results incl. tables

The melting temperature is defined as the temperature at which the phase transition from solid to liquid state takes place at normal atmospheric pressure. This temperature ideally corresponds to the solidification or freezing temperature.

Preliminary Test

Starting at 225°C, the weight of the sample decreased significantly. At 291°C, the sample weight had decreased by 25%.

After the experiment, a black charred residue remained in the sample container (original colour: grey). The change of the colour indicated reaction and/or decomposition of the test item.

Main Study

An endothermic peak was observed between 100°C and 175°C followed by a broad endothermic effect starting at 200°C. The extrapolated onset temperature of the first peak was 141.252°C. The endothermic effect was most likely obtained due to melting of the test item. The second endothermic effect was probably obtained due to reaction and/or decomposition of the test item.

After the experiment, a black charred residue remained in the sample container (original colour: grey). Based on this visual observation, it was found that the test item reaction and/or decomposition of the test item.

In order to investigate the melting peak, Experiment 2 was stopped directly after the melting peak. The extrapolated onset temperature was 141.060°C. After the experiment, an orange brown molten residue remained in the sample container (original colour: grey). Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.

The melting temperature was determined as the mean melting temperature of Experiment 1 (141.252°C) and Experiment 2 (141.060°C).

The melting temperature ofthe test itemwas 141.2°C (414.3K).Reaction and/or decomposition of the test itemwas observed during melting at the DSC experiments. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature

Applicant's summary and conclusion

Conclusions:
The melting temperature of the test item was 141.2°C (414.3K).

Reaction and/or decomposition of the test item was observed during melting at the DSC experiments. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.
Executive summary:

The melting temperature of NBTRI was determined by DSC. The melting temperature of the test itemwas 141.2°C (414.3K).

Reaction and/or decomposition of the test item was observed during melting at the DSC experiments.