Reaction mass of 2-(((1-(methacryloyloxy)propan-2-yl)oxy)carbonyl)benzoic acid and 2-((2-(methacryloyloxy)propoxy)carbonyl)benzoic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Remarks:

The study described in this report was conducted in a facility which operates in accordance with Good Laboratory Practice principles; however, no claim of GLP compliance was intended nor is made for this study.

Type of method:

flask method

Specific details on test material used for the study:

Identification: Methacryloxyisopropyl acid phthalate
Appearance/Physical state: clear yellow liquid
Batch: YY00GCV000
Purity: 62.8%
Expiry date: 31 December 2017
Storage conditions: room temperature in the dark

Key result

Water solubility:

2.82 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 2.83 - <= 2.87

Preliminary Test Results:

The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 1.13 g/L. The solution had a pH of 3.16.

Definitive Test Results:

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Solution	Mean Peak Area
Standard 502 mg/L	3.2749 x 10^7
Standard 502 mg/L	3.2797 x 10^7
Sample 1A	9.0516 x 10^7
Sample 1B	9.1803 x 10^7
Sample 2A	9.3239 x 10^7
Sample 2B	9.3117 x 10^7
Sample 3A	9.2064 x 10^7
Sample 3B	9.2358 x 10^7

The concentration (g/L) of test item in the sample solutions is shown in the following table:

Sample Number	Time Shaken at ~ 30°C (hours)	Concentration (g/L)	Solution pH
1	24	2.79	2.83
2	48	2.85	2.83
3	72	2.82	2.87

Mean concentration : 2.82 g/L at 20.0 ± 0.5 ºC

Range : 2.79 to 2.85 g/L

Standard Deviation : 3.09 x 10^-2

Validation:

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 100 to 1000 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 being obtained.

Discussion:

On completion of the equilibration period, the samples were clear and colorless with excess test item present in the test vessels. After filtration, the supernatant was taken for analysis. The supernatant was visually observed to be free from un-dissolved test item.

As the water solubility was determined during the preliminary test to be above 10-2 g/L, the flask shaking test was performed.

All individual water solubility results were within ± 15% of the mean, thus satisfying the criteria specified in the guidelines.

Conclusions:

The water solubility of the test item has been determined to be 2.82 g/L of solution at 20.0 ± 0.5 °C. The solutions had pH in the range of 2.83 to 2.87.

Executive summary:

Water Solubility. 2.82 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

Water Solubility. 2.82 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Key value for chemical safety assessment

Water solubility:

2.82 g/L

at the temperature of:

20 °C