Triethyl O-acetylcitrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1959

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Older study: meets scientific standards with acceptable restrictions (limited number of animals in study, partly limited documentation)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Toxicology of the Citric Acid Esters: Tributyl Citrate, Acetyl Tributyl Citrate, Triethyl Citrate, and Acetyl Triethyl Citrate

Author:

Finkelstein M & Gold H

Year:

1959

Bibliographic source:

Toxicol Applied Pharmacol 1, 283 - 298

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1959

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Study from 1959 (no guidelines available at the time the study was performed)

GLP compliance:

no

Remarks:

Study from 1959 (GLP was not compulsory at the time the study was performed)

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl O-acetylcitrate

EC Number:

201-066-5

EC Name:

Triethyl O-acetylcitrate

Cas Number:

77-89-4

Molecular formula:

C14H22O8

IUPAC Name:

triethyl 2-acetoxypropane-1,2,3-tricarboxylate

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

Single dosing with 5 - 15 mL/kg (ca. 5 - 15 g)

No. of animals per sex per dose:

Dosed was a group of 5 animals (no further details reported)

Control animals:

not specified

Details on study design:

Duration of observation period following administration: 21 d
Frequency of observations and weighing: not reported
Necropsy of survivors performed: not reported
Other examinations performed: body weight,organ weights, histopathology

Statistics:

Not further specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 7 000 mg/kg bw

Mortality:

Deaths occured at any dose level throughout the study.

Clinical signs:

other: The signs included weakness, depression, ataxia, hyperexcitability, unrest, urinary dribbling, irregular and labored respiration, and in the advanced phase of poisoning convulsions appeared in some of the animals.

Gross pathology:

Not reported

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

In this older study with Wistar rats the LD50 was estimated with ca. 7000 mg/kg.

Executive summary:

In this older study Wistar rats were dosed once with 5 - 15 mL/kg (ca. 5000 - 15000 mg/kg) via gavage. All animals were observed for signs of toxicity for 21 d following dosing. The dosing caused no deaths and the estimated LD50 was given with 7 mL/kg (ca. 7000 mg/kg).