Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-269-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study on rats, the Oral LD50 was found to be superior to 5 mL/kg. (pre- GLP, Rel. K2)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study performed similar to the OECD Guideline 401, a single dose of 5 mL/kg bw of undiluted test substance was given by oral gavage to a group of 5 male and 5 female Sprague Dawley rats. Animals were then observed for mortality, clinical signs and body weight changes for 14 days, and were all sacrificed for macroscopic examinations.
Only 1 male died within a 48-hour period. Toxic symptoms consisted of slight salivation, slight ataxia, slight respiratory depression and a slight decrease in spontaneous activity started 1 hour after dosing and persisted through 4 hours. By 24 hours, all animals appeared normal except one male which was unconscious and died. Mean body weight gains in females and males were 44 and 88 g, respectively. No gross pathological changes were noted upon necropsy.
Rat Oral LD50 >5 mL/kg bw.
Justification for classification or non-classification
Self classification:
Acute toxicity via Oral route:
Based on the available data, the substance is not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is greater than 5 mL/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
