Registration Dossier
Registration Dossier
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EC number: 202-912-6 | CAS number: 101-07-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1953
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 953
- Report date:
- 1953
Materials and methods
- Principles of method if other than guideline:
- Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-[bis(2-ethylhexyl)amino]ethanol
- EC Number:
- 202-912-6
- EC Name:
- 2-[bis(2-ethylhexyl)amino]ethanol
- Cas Number:
- 101-07-5
- Molecular formula:
- C18H39NO
- IUPAC Name:
- 2-[bis(2-ethylhexyl)amino]ethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- A sample of di (2-ethylhexyl) ethanolamine (S-5223) was received from S. Charleston on 11-12-52 for toxicological assay.
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- Substantially saturated vapor
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- Animals observed for 14 days.
Results and discussion
- Mortality:
- None.
- Clinical signs:
- other: Slight irritation of extremities.
Applicant's summary and conclusion
- Conclusions:
- Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.
- Executive summary:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.
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