Registration Dossier
Registration Dossier
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EC number: 903-982-7 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: A scientific review (peer reviewed). No data on test method. No data on GLP.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
Skin absorption of fenchyl acetate was assessed in 5 male mice.
- Short description of test conditions: An area of 2.2 cm2 on the shaved abdominal skin was used. Eserine (0.23%) was used as an indicator and the test material was used as a carrier for eserine.
- Parameters analysed / observed: The latency period between application to the skin and the appearance of the eserine effect in the periodically stimulated masticatory muscles was used as a measure of the absorption rate. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,3-dimethyl-8,9-dinorbornan-2-yl acetate
- EC Number:
- 237-588-5
- EC Name:
- 3,3-dimethyl-8,9-dinorbornan-2-yl acetate
- Cas Number:
- 13851-11-1
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 1,3,3-trimethylbicyclo[2.2.1]hept-2-yl acetate
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- No. of animals per group:
- 5
- Details on study design:
- An area of 2.2 cm2 on the shaved abdominal skin was used. Eserine (0.23%) was used as an indicator and the test material was used as a carrier for eserine. The latency period between application to the skin and the appearance of the eserine effect in the periodically stimulated masticatory muscles was used as a measure of the absorption rate.
Results and discussion
Any other information on results incl. tables
Dermal absorption of fenchyl acetate was moderately slow (54 min) in mice.
Applicant's summary and conclusion
- Conclusions:
- Dermal absorption of fenchyl acetate was moderately slow (54 min) in mice.
- Executive summary:
Skin absorption of fenchyl acetate was assessed in 5 male mice. An area of 2.2 cm2 on the shaved abdominal skin was used. Eserine (0.23%) was used as an indicator and the test material was used as a carrier for eserine. The latency period between application to the skin and the appearance of the eserine effect in the periodically stimulated masticatory muscles was used as a measure of the absorption rate. Dermal absorption of fenchyl acetate was moderately slow (54 min) in mice.
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