Registration Dossier
Registration Dossier
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EC number: 277-962-5 | CAS number: 74665-14-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature reference
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- Non occlusive application. Each animal was treated simulteneously at 4 application sites. 2 substances was tested at different concentrations on one animal in order to reduce the risk of any synergistic effects. Four hours exposure
- GLP compliance:
- no
Test material
- Reference substance name:
- Toluene sulphonic acid
- IUPAC Name:
- Toluene sulphonic acid
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- PTSA monohydrate 0.5-60% aqueous solutions
- Duration of treatment / exposure:
- 4 hours
- Details on study design:
- Non occlusive application. Each animal was treated simulteneously at 4 application sites. 2 substances was tested at different concentrations on one animal in order to reduce the risk of any synergistic effects. In the case of PTSA, the animals were exposed parallely to ethylene diamine, hydrofluoric acid, morpholine, sodium bifluoride, sodium hypochloride or propionic acid.
Results and discussion
In vivo
Results
- Remarks on result:
- other: not available
- Irritant / corrosive response data:
- Four hours exposure to 0.5% PTSA solution only caused irritation in one of three animals, while concentrations of 20-60% caused necrosis with subsequent scar formation
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Conclusions:
- Four hours exposure to 0.5% PTSA solution only caused irritation in one of three animals, while concentrations of 20-60% caused necrosis with subsequent scar formation
- Executive summary:
Non occlusive application. Each animal was treated simulteneously at 4 application sites. 2 substances was tested at different concentrations on one animal in order to reduce the risk of any synergistic effects. In the case of PTSA, the animals were exposed parallely to ethylene diamine, hydrofluoric acid, morpholine, sodium bifluoride, sodium hypochloride or propionic acid.
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