Registration Dossier

Administrative data

Endpoint:
skin sensitisation, other
Remarks:
in vivo
Type of information:
(Q)SAR
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited

Data source

Reference
Reference Type:
other: QSAR model
Title:
Skin Sensitization model (CAESAR) 2.1.6

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Reference
Name:
Unnamed
Details on test material:
The SMILES included in the reference substance linked in Section 1 (General information) was used as model input.

Results and discussion

In vitro / in chemico

Other effects / acceptance of results:
The substance is predicted to be a skin sensitizer.

Any other information on results incl. tables

The result appears non-reliable as the predicted compound is outside the applicability domain of the model.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Conclusions:
The substance is predicted to be a skin sensitizer.