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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE
OECD Toolbox Version 3.4

2. SMILES
Isomer 1, 5-Methacryloyloxy-1,3-dioxan : C=C(C)C(OC1COCOC1)=O
Isomer 2 4-Methacryloyloxymethyl-1,3-dioxolan : C=C(C)C(OCC1OCOC1)=O

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
2017
Report date:
2017
Reference Type:
other company data
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Principles of method if other than guideline:
- Software tool(s) used including version:
- Model used: OECD Toolbox 3.4
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction products of Glycerin formal and 2-Propenoic acid, 2-methyl-, methyl ester
EC Number:
945-527-5
Cas Number:
1620329-57-8
Molecular formula:
C8H12O4
IUPAC Name:
Reaction products of Glycerin formal and 2-Propenoic acid, 2-methyl-, methyl ester
Specific details on test material used for the study:
SMILES
Isomer 1, 5-Methacryloyloxy-1,3-dioxan : C=C(C)C(OC1COCOC1)=O
Isomer 2 4-Methacryloyloxymethyl-1,3-dioxolan : C=C(C)C(OCC1OCOC1)=O

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
265 mg/L
Basis for effect:
growth rate
Remarks on result:
other: QSAR
Remarks:
both isomers
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
197 mg/L
Basis for effect:
growth rate
Remarks on result:
other: QSAR
Remarks:
both isomers

Any other information on results incl. tables

Toxicity (EC50, 72 h, growth rate) of the target chemical (265 mg/L) is predicted from category members using trend analysis based on 15 values within the range 2.28 - 836 mg/L from 15 category members. Category members are single

chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

The target chemical FALLS within applicability domain of the prediction

The data used for calculating the current prediction is taken from 16 experimental values selected from the following database(s):

1. ECHA CHEM (studies on behalf of the registrant)

Toxicity (NOEC, 72 h, growth rate) of the target chemical (196 mg/L) is predicted from category members using trend analysis based on

14 values within the range 0.251 - 400 mg/L from 14 category members. Category members are single

chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having

experimental data are listed in the category.

The target chemical FALLS within applicability domain of the prediction (see Section 4.3 for details).

The data used for calculating the current prediction is taken from 15 experimental values selected from

the following database(s):

1. ECHA CHEM (studies on behalf of the registrant)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
The target chemical FALLS within applicability domain of the prediction
Conclusions:
EC50 Algae (72 h) growth rate of Glycerolformal methacrylate (both isomers) is 265 mg/l based mg/l on QSAR predicted from category members using trend analysis is predicted from category members using trend analysis based on
15 values within the range 2.28 - 836 mg/L from 15 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

NOEC Algae (72h) growth rate of Glycerolformal methacrylate (both isomers) is 197 mg/l based mg/l on QSAR predicted from category members using trend analysis is predicted from category members using trend analysis based on
15 values within the range 0.251 - 400 mg/L from 15 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.
Executive summary:

EC50 Algae (72 h) growth rate of Glycerolformal methacrylate (both isomers) is 265 mg/l based mg/l on QSAR predicted from category members using trend analysis is predicted from category members using trend analysis based on

15 values within the range 2.28 - 836 mg/L from 15 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

NOEC Algae (72h) growth rate of Glycerolformal methacrylate (both isomers) is 197 mg/l based mg/l on QSAR predicted from category members using trend analysis is predicted from category members using trend analysis based on

15 values within the range 0.251 - 400 mg/L from 15 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

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