Reaction products of Glycerin formal and 2-Propenoic acid, 2-methyl-, methyl ester

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

1. SOFTWARE
OECD Toolbox Version 3.4

2. SMILES
Isomer 1, 5-Methacryloyloxy-1,3-dioxan : C=C(C)C(OC1COCOC1)=O
Isomer 2 4-Methacryloyloxymethyl-1,3-dioxolan : C=C(C)C(OCC1OCOC1)=O

Guideline:

other: REACH Guidance on QSARs

Specific details on test material used for the study:

SMILES
Isomer 1, 5-Methacryloyloxy-1,3-dioxan : C=C(C)C(OC1COCOC1)=O
Isomer 2 4-Methacryloyloxymethyl-1,3-dioxolan : C=C(C)C(OCC1OCOC1)=O

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

314 mg/L

Basis for effect:

mortality

Remarks on result:

other: prediction for both isomers

Toxicity of the target chemical (314 mg/L) is predicted from category members using trend analysis based on 11 values within the range 2.57 - 380 mg/L from 11 category members. Category members are single

chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

The target chemical FALLS within applicability domain of the prediction.

The data used for calculating the current prediction is taken from 11 experimental values selected from the following database(s):

1. ECHA CHEM (Company is owner of the data)

Validity criteria fulfilled:

yes

Remarks:

The target chemical FALLS within applicability domain of the prediction

Conclusions:

EC50 Daphnia magna of Glycerolformal methacrylate (both isomers) is 314 mg/l based on QSAR predicted from category members using trend analysis based on 11 values within the range 2.57 - 380 mg/L from 11 category members. Category members are single
chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

Executive summary:

EC50 Daphnia magna of Glycerolformal methacrylate (both isomers) is 314 mg/l based on QSAR predicted from category members using trend analysis based on 11 values within the range 2.57 - 380 mg/L from 11 category members. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

Description of key information

EC50 (48h) Daphnia magna: 314 mg/l based on QSAR prediction.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

314 mg/L